Evolution and host-specific adaptation of Pseudomonas aeruginosa
We describe how Pseudmonas aeruginosa has evolved over the last 200 years into a global pathogen via horizontal gene transfer and then further specialised to infect people with cystic fibrosis or without via convergent molecular evolution.
Jul 1, 2024
Mutational spectra are associated with bacterial niche
Nov 1, 2023
Impact of transient acquired hypermutability on the inter- and intra-species competitiveness of Pseudomonas aeruginosa
Nov 1, 2023
Mycobacterium abscessus pathogenesis identified by phenogenomic analyses
Sep 1, 2022
Stepwise pathogenic evolution of textitMycobacterium abscessus
Apr 1, 2021
Protein antibiotics: mind your language
Jan 1, 2021
Producing polished prokaryotic pangenomes with the Panaroo pipeline
Panaroo is a a graph-based pangenome clustering tool that is able to account for many of the sources of error introduced during the annotation of prokaryotic genome assemblies. It's available at https://github.com/gtonkinhill/panaroo.
Jul 1, 2020
Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning-enabled molecular diagnostics
By training machine learning classifiers on information about the presence or absence of genes, their sequence variation, and expression profiles, we generated predictive models and identified biomarkers of resistance to four commonly administered antimicrobial drugs.
Mar 1, 2020
Genomics and prevalence of bacterial and archaeal isolates from biogas-producing microbiomes
Nov 1, 2017
Metagenomics and CAZyme Discovery
Jan 1, 2017